Reading Diary 4
Reading Diary 4
5 null terms
- adjacent
- Next to something.
- Example: Even more intriguingly, all 8 instances of T242N i 432 n subtype A1, of which 4 occurred in B*57:02-expressing individuals, never occurred with the subtype consensus Proline at the adjacent codon 243, suggesting that B*57:02 was pressuring HIV to escape via P243X in subtype A1.
N. N. Kinloch et al., “Genotypic and Mechanistic Characterization of Subtype-Specific HIV Adaptation to Host Cellular Immunity,” Journal of Virology, vol. 93, no. 1, Jan. 2019, doi: 10.1128/jvi.01502-18.
- en: Примыкающий, прилегающий.
- assess
- To make a judgement about the nature or quality of somebody/something.
- Example: Our observation that HLA-B*57:02 was significantly associated with Gag T242N in subtype A1 (p=1.9x10-6423 ; q=0.006) (Figure 3 and Table S1) was particularly intriguing, however we could not assess whether this association is differentially selected between subtypes A1 and D because only two individuals expressed B*57:02 in the latter group.
N. N. Kinloch et al., “Genotypic and Mechanistic Characterization of Subtype-Specific HIV Adaptation to Host Cellular Immunity,” Journal of Virology, vol. 93, no. 1, Jan. 2019, doi: 10.1128/jvi.01502-18.
- en: Оценивать, определять.
- eligibility
- The state of being able to have or do something because you have the right qualifications, are the right age, etc.
- Example: We did not deliberately select cohort subsets to have comparable clinical profiles. Rather, this likely reflects the fact that we studied the baseline (pre-therapy) cross section of two HIV treatment cohorts (see methods) - and treatment eligibility is guided in part by immunological (CD4+ T-cell count) criteria.
N. N. Kinloch et al., “Genotypic and Mechanistic Characterization of Subtype-Specific HIV Adaptation to Host Cellular Immunity,” Journal of Virology, vol. 93, no. 1, Jan. 2019, doi: 10.1128/jvi.01502-18.
- en: приемлемость, правомочность.
- preclude
- To prevent something from happening or somebody from doing something; to make something impossible.
- Example: Power limitations also precluded us from investigating certain associations more fully.
N. N. Kinloch et al., “Genotypic and Mechanistic Characterization of Subtype-Specific HIV Adaptation to Host Cellular Immunity,” Journal of Virology, vol. 93, no. 1, Jan. 2019, doi: 10.1128/jvi.01502-18.
- en: Препятствовать, мешать, предотвращать.
- putative
- Believed to be the person or thing mentioned.
- Example: The putative B*15:03-restricted epitope RL9/QL9 (Nef codons 104-112), discovered via differential B*15:03-mediated escape via Nef K105R, is unlikely to be immunogenic in subtype D due to weaker binding of its cognate sequence to this allele.
N. N. Kinloch et al., “Genotypic and Mechanistic Characterization of Subtype-Specific HIV Adaptation to Host Cellular Immunity,” Journal of Virology, vol. 93, no. 1, Jan. 2019, doi: 10.1128/jvi.01502-18.
- en: предполагаемый, предположительный